郭林

人物经历学历

学士. 1983，武汉大学生物系。

硕士. 1986, 武汉大学生物系。

博士. 1991, 美国内华达大学生物化学系。

博士后， 1993－1995，美国弗吉利亚大学。

博士后， 1995－1998，美国华盛顿大学。

主要工作

1998-2005.7， Immunex公司/Amgen公司，美国西雅图，历任初级科学家、科学家、高级科学家。

2005.8.– 武汉大学生命科学学院教授。

主讲课程

科技英文写作基础，每周2学时，2005年秋季，硕士研究生。生物化学，每周5学时，2006年秋季，本科生国际班。

研究方向

蛋白质组学

目前主要研究领域和兴趣：

本实验室以蛋白质组学及生物质谱学为主要研究方法，重点研究感染与天然免疫过程中的蛋白组变化以及蛋白质信号传导通路。

主要贡献

代表性论文

Zeng, H. L., Rao, X., Zhang, L. K., Zhao, X., Zhang, W. P., Wang, J., Xu, F., and Guo, L. (2014) Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome,J Proteomics

109

, 125-142。

Yao, Q., Liu, B. Q., Li, H., McGarrigle, D., Xing, B. W., Zhou, M. T., Wang, Z., Zhang, J. J., Huang, X. Y., and Guo, L. (2014) C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2,J Biol Chem

289

, 12666-12678。

Zhao, X., Sidoli, S., Wang, L., Wang, W., Guo, L., Jensen, O. N., and Zheng, L. (2014) Comparative proteomic analysis of histone post-translational modifications upon ischemia/reperfusion-induced retinal injury,J Proteome Res

13

, 2175-2186。

Yan, J., Tian, H., Wang, S., Shao, J., Zheng, Y., Zhang, H., Guo, L., and Ding, Y. (2014) Pollen developmental defects in ZD-CMS rice line explored by cytological, molecular and proteomic approaches,J Proteomics

108C

, 110-123。

Zhang, L. K., Chai, F., Li, H. Y., Xiao, G., and Guo, L. (2013) Identification of host proteins involved in Japanese encephalitis virus infection by quantitative proteomics analysis,J Proteome Res

12

, 2666-2678。

Xing, B., Wang, L., Guo, D., Huang, J., Espenel, C., Kreitzer, G., Zhang, J. J., Guo, L., and Huang, X. Y. (2013) Atypical protein kinase Clambda is critical for growth factor receptor-induced dorsal ruffle turnover and cell migration,J Biol Chem

288

, 32827-32836。

Wu, Y., Zhao, S., Tian, H., He, Y., Xiong, W., Guo, L., and Wu, Y. (2013) CPK3-phosphorylated RhoGDI1 is essential in the development of Arabidopsis seedlings and leaf epidermal cells,J Exp Bot

64

, 3327-3338。

Li, X. S., Pan, Y. N., Zhao, Y., Yuan, B. F., Guo, L., and Feng, Y. Q. (2013) Preparation of titanium-grafted magnetic mesoporous silica for the enrichment of endogenous serum phosphopeptides,J Chromatogr A

1315

, 61-69。

Hou, D., Zhang, L., Deng, F., Fang, W., Wang, R., Liu, X., Guo, L., Rayner, S., Chen, X., Wang, H., and Hu, Z. (2013) Comparative Proteomics Reveal Fundamental Structural and Functional Differences between the Two Progeny Phenotypes of a Baculovirus,J Virol

87

, 829-839。

Chen, X., Zhao, Y., Li, G.-M., and Guo, L. (2013) Proteomic analysis of mismatch repair-mediated alkylating agent-induced DNA damage response,Cell & Biosciences

⊥11

, 37。

Xu, H., Zhang, W., Gao, Y., Zhao, Y., Guo, L., and Wang, J. (2012) Proteomic analysis of embryo development in rice (Oryza sativa),Planta

235

, 687-701。

Liu, G., Tian, H., Huang, Y. Q., Hu, J., Ji, Y. X., Li, S. Q., Feng, Y. Q., Guo, L., and Zhu, Y. G. (2012) Alterations of Mitochondrial Protein Assembly and Jasmonic Acid Biosynthesis Pathway in Honglian (HL)-type Cytoplasmic Male Sterility Rice,J Biol Chem

287

, 40051-40060。

Kang, X., Chen, X., He, Y., Guo, D., Guo, L., Zhong, J., and Shu, H. B. (2012) DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication,Virology。

Chen, C., Wu, D., Zhang, L., Zhao, Y., and Guo, L. (2012) Comparative phosphoproteomics studies of macrophage response to bacterial virulence effectors,J Proteomics

77

, 251-261。

Yu, J. L., and Guo, L. (2011) Quantitative proteomic analysis of Salmonella enterica serovar Typhimurium under PhoP/PhoQ activation conditions,J Proteome Res

⊥1110⊥

, 2992-3002。

Yao, Q., Li, H., Liu, B. Q., Huang, X. Y., and Guo, L. (2011) SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses,J Biol Chem

286

, 27342-27349。

Xu, H., Zhang, W., Gao, Y., Zhao, Y., Guo, L., and Wang, J. (2011) Proteomic analysis of embryo development in rice (Oryza sativa),Planta。

Wu, J. H., Li, X. S., Zhao, Y., Zhang, W., Guo, L., and Feng, Y. Q. (2011) Application of liquid phase deposited titania nanoparticles on silica spheres to phosphopeptide enrichment and high performance liquid chromatography packings,J Chromatogr A

1218

, 2944-2953。

Shao, J., Zhang, Y., Yu, J., Guo, L., and Ding, Y. (2011) Isolation of Thylakoid Membrane Complexes from Rice by a New Double-Strips BN/SDS-PAGE and Bioinformatics Prediction of Stromal Ridge Subunits Interaction,PLoS One

⊥11
, e20342。

Chen, X., Wu, D., Zhao, Y., Wong, B. H., and Guo, L. (2011) Increasing phosphoproteome coverage and identification of phosphorylation motifs through combination of different HPLC fractionation methods,J Chromatogr B Analyt Technol Biomed Life Sci

879

, 25-34。

Wu, J. H., Zhao, Y., Li, T., Xu, C., Xiao, K., Feng, Y. Q., and Guo, L. (2010) The use of liquid phase deposition prepared phosphonate grafted silica nanoparticle-deposited capillaries in the enrichment of phosphopeptides,J Sep Sci

33

, 1806-1815。

Wang, R., Deng, F., Hou, D., Zhao, Y., Guo, L., Wang, H., and Hu, Z. (2010) Proteomics of the Autographa californica nucleopolyhedrovirus budded virions,J Virol

84

, 7233-7242。

Ma, Y., Zhao, Y., Zhao, R., Zhang, W., He, Y., Wu, Y., Cao, Z., Guo, L., and Li, W. (2010) Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis,Proteomics

⊥1110⊥

, 2471-2485。

Zhou, Z., Fan, J. B., Zhu, H. L., Shewmaker, F., Yan, X., Chen, X., Chen, J., Xiao, G. F., Guo, L., and Liang, Y. (2009) Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding,J Biol Chem

284

, 30148-30158。

Deng, M., Li, F., Ballif, B. A., Li, S., Chen, X., Guo, L., and Ye, X. (2009) Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17,J Biol Chem

284

, 7875-7888。

Lin, B., Li, T., Zhao, Y., Huang, F. K., Guo, L., and Feng, Y. Q. (2008) Preparation of a TiO2 nanoparticle-deposited capillary column by liquid phase deposition and its application in phosphopeptide analysis,J Chromatogr A

1192

, 95-102。

Deng, F., Wang, R., Fang, M., Jiang, Y., Xu, X., Wang, H., Chen, X., Arif, B. M., Guo, L., and Hu, Z. (2007) Proteomics analysis of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus identified two new occlusion-derived virus-associated proteins, HA44 and HA100,J Virol

81

, 9377-9385?。