林鑫华

人物经历教育经历时间院校专业学位1984年杭州大学生物系学士1987年中国科学院上海细胞生物学研究所硕士1995年美国圣路易斯华盛顿大学博士工作经历

2000-2009年，美国辛辛那提大学儿童医院医学中心，先后任助理教授（2000）、副教授（2005）、教授（2008）[2]。

2009-2016年，中国科学院动物研究所，研究员、膜生物学国家重点实验室主任。

2016年7月起，任复旦大学遗传学研究所所长，主要从事发育遗传和干细胞生物学的研究。

现为复旦大学生命科学学院执行院长，复旦大学遗传学研究所所长，复旦大学遗传工程国家重点实验室主任。

主要成就

科研成就

以果蝇和小鼠为模式动物，并结合人源干细胞体外培养体系，研究Wnt、BMP、 Hh、JAK/STAT 等信号通路的调控机制；研究信号转导、转录调控和表观遗传对内脏器官（肠、肺等）的稳态维持、组织再生和干细胞调控的作用机制；探讨信号转导、遗传变异和表观遗传在发育和干细胞调控、以及相关人类疾病（如肿瘤、先天性缺陷等）中的作用机制。

在国际核心期刊上发表论文共70余篇。许多成果被Nature综述类杂志重点介绍；蛋白糖在形态发生素浓度梯度形成的研究，被认为是发育生物学领域的重大发现；对Wnt蛋白的分泌、分布以及信号转导的贡献获得发育生物学家们的一致肯定；近年来有关内脏器官的稳态维持和干细胞领域的研究也获得同行专家的广泛关注和认可。

代表性成果

1. Zhang, X., Chen, Y., Ye, Y., Wang, J., Wang, H., Yuan, G., Lin, Z., Wu, Y., Zhang, Y.,?Lin, X. (2016) Wnt signaling promotes hindgut fate commitment through regulating multi-lineage genes during hESC differentiation.?Cellular Signaling?(In Press)

2. Ren, W., Zhang, Y., Li, M., Wu, L., Wang, G., Baeg, GH., You, J., Li, Z.,?Lin, X.(2015) Windpipe controls?Drosophila?intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation.?PLOS Genetics, 11(4): e1005180.

3. Li, Z., Guo, Y., Han, L., Zhang, Y., Shi, L., Huang, X.,?Lin, X.(2014) Debra-mediated Ci degradation controls tissue homeostasis in?Drosophila?adult midgut.?Stem cell reports, 2(2):135-144

4. You, J., Zhang, Y., Li, Z., Lou, Z., Jin, L.,?Lin, X. (2014)?Drosophila?Perlecan Regulates Intestinal Stem Cell Activity via Cell-Matrix Attachment.?Stem cell reports, 2(6):761-769

5. Huang, Q., Tang, X., Wang, G., Fan, Y., Ray, L., Bergmann, A., Belenkaya, T., Ling, X., Yan, D., Lin, Y., Shi, W., Ye, X., Zhou, X., Lu, F., Qu, J.,?Lin, X.(2014) Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in?Drosophila.?Cell Death & Differentiation, 21(12):1961-70

6. Li, Z., Zhang, Y., Han, L., Shi, L., and?Lin, X. (2013) Trachea-derived Dpp controls adult midgut homeostasis in?Drosophila.?Developmental Cell, 24(2):133-143

7. Zeng, X.,?Lin, X., Hou, SX. (2013) The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult?Drosophila?intestine.?Development, 140(17): 3532-354

8. Zhang, P., Wu, Y., Belenkaya, T. and?Lin, X. (2011) SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless.?Cell Research, 21(12):1677-1690

9. Yang, Y.,?Lin, X. (2010) Hedgehog signaling uses lipid metabolism to tune smoothened activation.?Developmental Cell, 19(1):3-4

10. Yan, D., Wu, Y., Yang, Y., Belenkaya, T., Tang, X.,?Lin, X. (2010) The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development.?Development, 137(12):2033-44

11. Yan, D.,Wu, Y., Feng, Y., Lin, S.,?Lin, X.(2009) The Core Protein of Glypican Dally-Like Determines Its Biphasic Activity in Wingless Morphogen Signaling.?Developmental Cell, 17(4):470-481.

12. Belenkaya, T., Wu, Y., Tang, X., Zhou, B., Cheng, L., Sharma, Y., Yan, D., Selva, E.M., and?Lin, X. (2008). The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network.?Developmental Cell, 14(1):120-131

13. Yan, D.,?Lin, X. (2008) Gylpican shows its versatility in Hh signaling.?Nature Cell Biology, 10 (7), 761-763

14. Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D., Asashima, M., Wylie.C.C,?Lin, X., and Heasman, J. (2005) Maternal Wnt11 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embryos.?Cell, 120(6): 857-871

15. Belenkaya, T., Han, C. Yan, D., Opoka, R.J., Khodoun, M., Liu, H., and?Lin, X. (2004)?Drosophila?Dpp morphogen movement is independent of dynamin-mediated endocytosis and is controlled by glypican members of heparan sulfate proteoglycans.?Cell, 119(2): 231-44

16. Han, C., Belenkaya, T., Wang, B., and?Lin, X.(2004)?Drosophila?glypicans control the cell-to-cell movement of Hedgehog by a dynamin independent process.?Development, 131, 601-11

17. Liu, C., Li, Y., Semenov, M., Han,C., Baeg, G-H.,Tan, Y., Zhang, Z.,?Lin, X., and He, Xi.(2002) Control of b-catenin phosphorylation-degradation by a dual-kinase mechanism.?Cell, 108 (6): 837-47

18.?Lin, X. and Perrimon, N. (1999) Dally cooperates with?Drosophila?Frizzled 2 to transduce Wingless signalling.?Nature, 400, 281-284.

社会活动

中国细胞生物学会发育生物学分会会长。

中国遗传学会发育遗传专业委员会副主任。

北京细胞生物学会副理事长。

中国细胞生物学会常务理事。

中国动物学会常务理事。

国际期刊 Developmental Dynamics、Fly编委，担任《细胞生物学学报》副主编。