汪晖

人物简介

1991年药理学硕士毕业后留校任教，2002和2004年分赴英国Institute of Food Research分子生化实验室和美国Howard University药学院进行合作研究。现为医学院药理学系教授、博士生导师。兼任系主任，校工会副主席、基础医学院副院长。

药理学系主任，兼国家中医药管理局武汉大学中药药理三级实验室主任、武汉大学食品与药品评价研锚点究中心主任。

社会兼职情况：

1.国家自然科学基金第十二、十三届药物药理学学科评审组成员；

2.国家食品药品监督管理局化妆品审评专家；

3.国家食品药品监督管理局药品审评专家；

4.武汉药理学会理事长。

研究方向

药物靶标与新药研发、外源物发育毒理。

主要贡献主持科研项目

1.国家自然科学基金项目重大国际合作“外源物孕期暴露所致子代骨关节炎易感及宫内内分泌代谢编程机制（批准号：81220108026）”，2013-2017

2.国家自然科学基金重点项目“胎海马GR介导外源物所致HPA轴发育异常的表观遗传机制（批准号：30830112）”， 2009-2012

3.教育部科学研究重大项目“代谢综合征的宫内起源机制及早期诊治技术研究（批准号：V200801）”，2012-2014

4.国家自然科学基金“高GC活化代谢介导外源物所致胎肝代谢编程改变的信号转导机制”，2011-2013

5.国家自然科学基金“胎肾上腺StAR/CYP11A1介导外源物所致宫内发育迟缓的分子机制（批准号：30672566）”，2007-2009

6.国家自然科学基金“肝星状细胞异物代谢特征及其在星状细胞激活中的作用（批准号：0371666）”， 2004-2006

7.湖北省自然科学基金创新群体“代谢组学技术确证宫内发育迟缓早期筛查诊断的生物标志物（批准号：2009CDA079）”，2009-2010

主持教学项目

教育部国家级教学团队“医学机能实验学”，2010-2012。

主要论文论著

1.Xu D, Wu Y, Liu F, Liu YS, Shen L, Lei YY, Liu J, Ping J, Qin J, Zhang C, Chen LB, Magdalou J, Wang H*. A hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion. Toxicol Appl Pharmacol, 2012;264(3):395-403.

2.Liu YS, Xu D, Feng JH, Kou H, Liang G, Yu H, He XH, Zhang BF, Chen LB, Magdaloue J, Wang H*. Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways. Toxicol Appl Pharmacol. 2012;262:205-16.

3.Xiong J, Guo Y, Li LY, Hu H, Qu XL, Sun XZ, Liu SH, Wang H*. A herbal composition of Semen Hoveniae, Radix Puerariae and Fructus Schisandrae shows potent protective effects on acute alcoholic intoxication in rodent models. Evidence-Based Complementary and Alternative Medicine. 2012;2012:638197.

4.Qin J, Shang L, Ping AS, Li J, Li XJ, Yu H, Magdalou J, Chen LB, Wang H*. TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1beta-induced rat osteoarthritis chondrocytes in vitro. Arthritis Res Ther, 2012;14(6): R242.

5.Xu D, Zhang BJ, Liang G, Ping J, Kou H, Li XJ, Xiong J, Chen LB, Magdalou J, Wang H*. Caffeine-induced activated glucocorticoid metabolism in hippocampus causes hypothalamic-pituitary-adrenal axis inhibition in fetal rats. PloS ONE. 2012;7(9):e44497.

6.Tan Y, Liu J, Deng Y, Cao H, Xu D, Cu FL, Lei YY, Magdalou J, Wu M, Chen L, Wang H*. Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation. Toxicol lett. 2012;214(3):279-87.

7.Liu L, Liu F, Kou H, Zhang BJ, Xu D, Chen B, Chen LB, Magdalou J, Wang H*. Prenatal nicotine exposure induced a hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in IUGR offspring rats. Toxicol Lett. 2012;209:307-13.

8.Xu D, Liang G, Yan YE, He WW, Liu YS, Chen LB, Magdalou J, Wang H*. Nicotine-induced over-exposure to maternal glucocorticoid and activated glucocorticoid metabolism causes hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic alterations in fetal rats. Toxicol lett. 2012;209:282-90.

9.Ping J*, Lei Y, Liu L, Wang TT, Feng YH, Wang H*. Inheritable stimulatory effects of caffeine on steroidogenic acute regulatory protein expression and cortisol production in human adrenocortical cells. Chemico-Biological Interactions. 2012;195:68-75.

10.Huang J, Zhou S, Ping J, Pan XL, Liang G, Xu D, Kou H, Bao C, Wang H*. Role of p53-dependent placental apoptosis in the reproductive and developmental toxicities of caffeine in rodents. Clin Exp Pharmacol Physiol 2012;39:357-63.

11.Wang TT, Chen M, Liu L, Cheng HY, Yan YE, Feng YH, Wang H*. Nicotine induced CpG methylation of Pax6 binding motif in StAR promoter reduces the gene expression and cortisol production. Toxicol Appl Pharmacol. 2011;257:328-37.

12.Li Y, Yan YY, Wang H*. Enhancement of placental antioxidative function and P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco/alcohol exposure. Environ Toxicol Pharmacol. 2011;32:465-71.

13.Xu D, Chen M, Pan XL, Xia LP, Wang H*. Dexamethasone induces fetal developmental toxicity through affecting the placental glucocorticoid barrier and depressing fetal adrenal function. Environ Toxicol Pharmacol. 2011;32:356-63.

14.Liang G, Chen M, Pan XL, Zheng J, Wang H*. Ethanol-induced inhibition of fetal hypothalamic-pituitary-adrenal axis due to prenatal overexposure to maternal glucocorticoid in mice. Exp Toxic Pathol. 2011;63:607-11.

15.Ping J, Li JT, Liao ZX, Shang L, Ao Y, Wang H*. Indole-3-carbinol inhibits hepatic stellate cells proliferation by blocking NADPH oxidase/reactive oxygen species/p38 MAPK pathway. Euro J Pharmacol 2011;650(2-3):656-62.

16.Xu D, Chen M, Guo Y, Liang G, Zhang BJ, Tan JQ, Magdalou J, Wang H*. Synergistic anti-fibrotic effect of verapamil and interferon in rats: partially based on enhanced verapamil oral bioavailability. Eur J Gastroenterol Hepatol. 2010; 22(4): 466-73.

17.Wang H*, Xu D, Chen M, Peng RX, Yue J. Testosterone-metabolizing capacity and characteristics ofadrenal microsomes in human fetus in vitro. J Pediatr Endocrinol Metab. 2010; 23:143-51.

发明专利

1.授权国家发明专利“一种检测HMG-CoA还原酶活性的改良分光光度法及应用”，专利号：ZL201110073398.8. 发明人：汪晖，郭喻，平洁，梁赅，王婷婷。

2.授权国家发明专利“一种预防和治疗骨髓炎的药物缓释制剂”，专利号：ZL201110048409.7. 发明人：汪晖，陈廖斌，曹洪，修涵，刘岩松。

3.授权国家发明专利“一种从当归中提取多糖的方法及应用”，专利号：ZL200810046965.9. 发明人：汪晖，陈廖斌，商亮，谭扬，李小军。

4.授权国家发明专利“一种从甘草中提取多糖的方法及应用”，申请号：ZL 200910061357.X. 发明人：汪晖，陈廖斌，李小军，汪巍，何文博，张逸杰，范雯。

5.授权国家发明专利“一种治疗骨髓炎的药物及制备方法”，专利号：ZL200510018246.2. 发明人：陈廖斌，汪晖，王钧，傅杰。

获奖记录

1.教学成果“基础医学本科探索性实验教学模式的构建与实践”，2009年获湖北省教学成果二等奖，为第一完成人。

2.科研成果“新型肝脏损伤早期标志物α-GST的确证及应用”，2011年通过湖北省科技厅主持的成果鉴定, 达国际先进水平；2012年获湖北省科技进步三等奖，为第一完成人。